Retinopathy of prematurity in English neonatal units: A national population-based analysis using NHS operational data
Authors: Wong, H.S., Santhakumaran, S., Statnikov, Y., Gray, D., Watkinson, M., Modi, N., Kadalraja, R., Kefas, J., Srinnel, S., Ramesh, C., Rackham, O., Brearey, S., Thirumurugan, A., Losa, I., McBride, T., Zipitis, C., Amegavie, L., Moise, J., Yadan, M., Maddock, N., Edi-Osagie, N., Heal, C., Birch, J., Al-Zidgali, F., Hasib, A., Kisat, H., Soe, A., Long, D., Fedee, J., Lama, M., Gupta, R., Rawlingson, De Boer, R.C., Rao, P., Blake, K., Bhaduri, A.K., Halahakoon, C., Deshpande, Mohite, A., Tewary, K.K., Palmer, K., Gallagher, A., Nycyk, J., Simmons, P., Morgen, I., Underhill, H.C., Mahesh Babu, R.N., Dalton, S., Dixon, H., James, M., Jayalal, V., Dyke, M., Babiker, S., Soe, T., Rubin, S., Ogilvy-Stuart, A., Evans, I., Wickham, T., Van Someren, V., Watkin, S., Blumberg, R., Sharief, N., Aladangady, N., Sharma, B., Sullivan, C., Alsford, L., Sharma, B., Khan, A., Hamdan, S., Ahmed, J.S., Foo, A., Talekar, R., Adiotomre, P., Gibson, A., Thomas, M., Mathur, R., Cruwys, M., Mannix, P., Ariff, H., Garbasa, M., Lal, M., Bosman, D., Fenton, A., Bolton, A.R., Abu-Harb, M., Verber, I., Olivier, J., Larson, J., Cherinet, Y., Munyard, P., Osbourne, N., Raman, M., Watts, T., Hannam, S., Walter, S., Kuna, J., Chang, Y.L., Shephard, R.
Journal: Archives of Disease in Childhood Fetal and Neonatal Edition
Publication Date: 01/01/2014
Volume: 99
Issue: 3
Pages: F196-F202
eISSN: 1468-2052
ISSN: 1359-2998
DOI: 10.1136/archdischild-2013-304508
Abstract:Objectives: To report on retinopathy of prematurity (ROP) screening compliance against a national guideline, factors associated with non-compliance and effect on ROP treatment. Design: National cohort study using operational NHS data from the National Neonatal Research Database (NNRD) for the period 2009-2011. Setting: 161 (94%) neonatal units in England. Population: Infants born below 32 weeks' gestation and/or with a birth weight below 1501 g. Main outcome measures: ROP screening status ('on-time', 'early', 'late', 'unknown') and associated infant and neonatal unit characteristics, ROP treatment. Results: The proportion of infants screened on-time increased over the study period (p<0.001). Of 19 821 eligible infants, 7602 (38.4%) were recorded to have received ROP screening in accordance with the national guideline; 7474 (37.8%) received screening outside the recommended time period; data were missing for 4745 (16.7%) infants. For 16 411 infants in neonatal care during the recommended screening period, late screening was significantly associated with lower gestational age (relative risk ratio (RRR) (95% credible interval) for late versus on-time screening 0.83 (0.80 to 0.86) for each increased week of gestation) and care in a neonatal unit providing less than 500 days of intensive care per annum (2.48 (0.99 to 4.99)). Infants screened late were almost 40% more likely to receive ROP treatment (OR (95% CI) 1.36 (1.05 to 1.76)). Conclusions: Understanding organisational differences between neonatal units may help improve ROP screening. Patient-level electronic NHS clinical data offer opportunity for future rapid, low cost, population-based evaluations but require improved data entry.
Source: Scopus
Preferred by: Minesh Khashu
Retinopathy of prematurity in English neonatal units: a national population-based analysis using NHS operational data.
Authors: Wong, H.S., Santhakumaran, S., Statnikov, Y., Gray, D., Watkinson, M., Modi, N., UK Neonatal Collaborative
Journal: Arch Dis Child Fetal Neonatal Ed
Publication Date: 05/2014
Volume: 99
Issue: 3
Pages: F196-F202
eISSN: 1468-2052
DOI: 10.1136/archdischild-2013-304508
Abstract:OBJECTIVES: To report on retinopathy of prematurity (ROP) screening compliance against a national guideline, factors associated with non-compliance and effect on ROP treatment. DESIGN: National cohort study using operational NHS data from the National Neonatal Research Database (NNRD) for the period 2009-2011. SETTING: 161 (94%) neonatal units in England. POPULATION: Infants born below 32 weeks' gestation and/or with a birth weight below 1501 g. MAIN OUTCOME MEASURES: ROP screening status ('on-time', 'early', 'late', 'unknown') and associated infant and neonatal unit characteristics, ROP treatment. RESULTS: The proportion of infants screened on-time increased over the study period (p<0.001). Of 19 821 eligible infants, 7602 (38.4%) were recorded to have received ROP screening in accordance with the national guideline; 7474 (37.8%) received screening outside the recommended time period; data were missing for 4745 (16.7%) infants. For 16 411 infants in neonatal care during the recommended screening period, late screening was significantly associated with lower gestational age (relative risk ratio (RRR) (95% credible interval) for late versus on-time screening 0.83 (0.80 to 0.86) for each increased week of gestation) and care in a neonatal unit providing less than 500 days of intensive care per annum (2.48 (0.99 to 4.99)). Infants screened late were almost 40% more likely to receive ROP treatment (OR (95% CI) 1.36 (1.05 to 1.76)). CONCLUSIONS: Understanding organisational differences between neonatal units may help improve ROP screening. Patient-level electronic NHS clinical data offer opportunity for future rapid, low cost, population-based evaluations but require improved data entry.
Source: PubMed
Retinopathy of prematurity in English neonatal units: a national population-based analysis using NHS operational data.
Authors: Wong, H.S., Santhakumaran, S., Statnikov, Y., Gray, D., Watkinson, M., Modi, N., UK Neonatal Collaborative
Journal: Archives of disease in childhood. Fetal and neonatal edition
Publication Date: 05/2014
Volume: 99
Issue: 3
Pages: F196-F202
eISSN: 1468-2052
ISSN: 1359-2998
DOI: 10.1136/archdischild-2013-304508
Abstract:Objectives
To report on retinopathy of prematurity (ROP) screening compliance against a national guideline, factors associated with non-compliance and effect on ROP treatment.Design
National cohort study using operational NHS data from the National Neonatal Research Database (NNRD) for the period 2009-2011.Setting
161 (94%) neonatal units in England.Population
Infants born below 32 weeks' gestation and/or with a birth weight below 1501 g.Main outcome measures
ROP screening status ('on-time', 'early', 'late', 'unknown') and associated infant and neonatal unit characteristics, ROP treatment.Results
The proportion of infants screened on-time increased over the study period (p<0.001). Of 19 821 eligible infants, 7602 (38.4%) were recorded to have received ROP screening in accordance with the national guideline; 7474 (37.8%) received screening outside the recommended time period; data were missing for 4745 (16.7%) infants. For 16 411 infants in neonatal care during the recommended screening period, late screening was significantly associated with lower gestational age (relative risk ratio (RRR) (95% credible interval) for late versus on-time screening 0.83 (0.80 to 0.86) for each increased week of gestation) and care in a neonatal unit providing less than 500 days of intensive care per annum (2.48 (0.99 to 4.99)). Infants screened late were almost 40% more likely to receive ROP treatment (OR (95% CI) 1.36 (1.05 to 1.76)).Conclusions
Understanding organisational differences between neonatal units may help improve ROP screening. Patient-level electronic NHS clinical data offer opportunity for future rapid, low cost, population-based evaluations but require improved data entry.Source: Europe PubMed Central