Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk
Authors: Dunlop, M.G., Dobbins, S.E., Farrington, S.M., Jones, A.M., Palles, C., Whiffin, N., Tenesa, A., Spain, S., Broderick, P., Ooi, L.-Y., Domingo, E., Smillie, C., Henrion, M., Frampton, M., Martin, L., Grimes, G., Gorman, M., Semple, C., Ma, Y.P., Barclay, E., Prendergast, J., Cazier, J.-B., Olver, B., Penegar, S., Lubbe, S., Chander, I., Carvajal-Carmona, L.G., Ballereau, S., Lloyd, A., Vijayakrishnan, J., Zgaga, L., Rudan, I., Theodoratou, E., Thomas, H., Maher, E., Evans, G., Walker, L., Halliday, D., Lucassen, A., Paterson, J., Hodgson, S., Homfray, T., Side, L., Izatt, L., Donaldson, A., Tomkins, S., Morrison, P., Brewer, C., Henderson, A., Davidson, R., Murday, V., Cook, J., Haites, N., Bishop, T., Sheridan, E., Green, A., Marks, C., Carpenter, S., Broughton, M., Greenhalge, L., Suri, M., Starr, J.M., Deary, I., Kirac, I., Kovacević, D., Aaltonen, L.A., Renkonen-Sinisalo, L., Mecklin, J.-P., Matsuda, K., Nakamura, Y., Okada, Y., Gallinger, S., Duggan, D.J., Conti, D., Newcomb, P., Hopper, J., Jenkins, M.A., Schumacher, F., Casey, G., Easton, D., Shah, M., Pharoah, P., Lindblom, A., Liu, T., Edler, D., Lenander, C., Dalén, J., Hjern, F., Lundqvist, N., Lindforss, U., Påhlman, L., Smedh, K., Törnqvist, A., Holm, J., Janson, M., Andersson, M., Ekelund, S., Olsson, L., Smith, C.G., West, H., Cheadle, J.P., MacDonald, G., Samuel, L.M., Ahmad, A., Corrie, P., Jodrell, D., Palmer, C., Wilson, C., O'Hagan, J., Smith, D., McDermott, R., Walshe, J., Cassidy, J., McDonald, A., Mohammed, N., White, J., Yosef, H., Breathnach, O., Grogan, L., Thomas, R., Eatock, M., Henry, P., Houston, R., Johnston, P., Wilson, R., Geh, I., Danwata, F., Hindley, A., Susnerwala, S., Bradley, C., Conn, A., Raine, A., Twelves, C., Falk, S., Hopkins, K., Tahir, S., Dhadda, A., Maraveyas, A., Sgouros, J., Teo, M., Ahmad, R., Cleator, S., Creak, A., Lowdell, C., Riddle, P., Benstead, K., Farrugia, D., Reed, N., Shepherd, S., Levine, E., Mullamitha, S., Saunders, M., Valle, J., Wilson, G., Jones, A., Weaver, A., Clark, P.I., Haylock, B., Iqbal, M.I., Myint, A.S., Smith, D., Beesley, S., Sevitt, T., Nicoll, J., Daniel, F., Ford, V., Talbot, T., Butt, M., Hamid, A., Mack, P., Roy, R., Osborne, R., McKinna, F., Alsab, H., Basu, D., Murray, P., Sizer, B., Azam, F.A., Neupane, R., Waterston, A., Glaholm, J., Blesing, C., Lowndes, S., Medisetti, A., Gaya, A., Leslie, M., Maisey, N., Ross, P., Dunn, G., Al-Salihi, O., Wasan, H.S., Palmer, C., Tan, L.T., Dent, J., Hofmann, U., Joffe, J.K., Sherwin, E., Soomal, R., Chakrabarti, A., Joseph, S., Van der Voet, J., Wadd, N.J., Wilson, D., Anjarwalia, S., Hall, J., Hughes, R., Polychronis, A., Scarffe, J.H., Hill, M., James, R.D., Shah, R., Summers, J., Hartley, A., Carney, D., McCaffrey, J., Bystricky, B., O'Reilly, S., Gupta, R., Al-Mishlab, T., Gidden, F., O'Hara, R., Stewart, J., Ashford, R., Glynne-Jones, R., Harrison, M., Mawdsley, S., Barlow, H., Tighe, M., Walther, J., Neal, J., Rees, C., Bridgewater, J., Karp, S., McGovern, U., Atherton, P.J., El-deeb, H., Macmillan, C., Patel, K., Bessell, E.M., Dickinson, P.D., Potter, V., Jephcott, C., McAdam, K., Wrigley, J., Osborne, R., Muthuramalingam, S., O'Callaghan, A., Bridgewater, J., Melcher, L., Braconi, C., Geh, J.I., Palmer, D., Narayana, P., Steven, N., Gaya, A., Maisey, N., Rudman, S., Chakraborti, P., Kelly, K., Macgregor, C., Whillis, D., Freebairn, A., Gildersleve, J., Sharif, S., Astras, G., Hickish, T., Beech, D., Ellis, R., Kulkarni, R., Shankland, K., Begent, R., Mayer, A., Meyer, T., Strauss, S., Hall, V., Raj, S., Chau, I., Cunningham, D., Birtle, A., Biswas, A., Susnerwala, S., Wise, M., Cummins, S., Essapen, S., Middleton, G., Topham, C., Langley, R., McKinna, F., Webb, A., Wilkins, M., Iveson, T.J., Dhadda, A., Hamid, A., Askill, C., Wagstaff, J., Azzabi, A., Bateman, A., Prejbisz, J., Tsang, D., Ali, N., Jones, A., O'Neill, P., Cottrill, C., Propper, D., Lofts, F.J., Kennedy, J., Anthoney, D.A., Cooper, R., Crellin, A., Melcher, A., Seymour, M., Baughan, C., Alexander, E., Cleator, S., Crown, J., Fennelly, D., Adab, F., Giridharan, S., Pedley, I., Wright, K., Bliss, P., Cogill, G., Lo, N., Toy, E., Bridgewater, J., Hochhauser, D., Ledermann, J., Brewster, A., Maughan, T., Mort, D., Mukherjee, S., Dobrowsky, W., Calvert, P., Leonard, G., Ahmad, R., Ford, H., Moody, A.M., Goriah, S., Wilkins, M., Clive, S., Dawson, L., McLean, C., Phillips, H.A., Gopi, K., Tomlinson, M., Clenton, S., Furniss, D., Hornbuckle, J., Pledge, S., Wadsley, J., Abbas, M., Marshall, E., Harper-Wynne, C., Barnes, A., Kumar, S., Vigneswaran, V., Farrugia, D., Webb, A., Gollins, S., Falk, S., Genton, M., Sparrow, G., Bale, C., Fuller, C., Mullard, A., Stuart, N., Williams, R., Keane, M., Maughan, T., Seymour, M., Wilson, R., Wasan, H., Adams, R., Madi, A., Cassidy, J., Kennedy, J., Hodgkinson, E., Rogers, P., Pope, M., Kaplan, R., Meade, A., Parmar, M., Kenny, S., Fisher, D., Harper, L., Mitchell, J., Nichols, L., Sydes, B., Clement, L., Kay, E., Courtney, C., Gallagher, M., Murphy, C., Thompson, L., Beall, S., Hassan, S., Gracie, R., Griffiths, G., Mason, M., Parker, C., Rudd, R., Johnson, P., Whelan, J., Northover, J., Brown, J., Aapro, M., Stout, R., Midgley, R., Kerr, D.J., Campbell, H., Tomlinson, I.P., Houlston, R.S.
Journal: Nature Genetics
Publication Date: 2012
eISSN: 1546-1718
ISSN: 1061-4036
Source: Scopus
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.
Authors: Dunlop, M.G., Dobbins, S.E., Farrington, S.M., Jones, A.M., Palles, C., Whiffin, N., Tenesa, A., Spain, S., Broderick, P., Ooi, L.-Y., Domingo, E., Smillie, C., Henrion, M., Frampton, M., Martin, L., Grimes, G., Gorman, M., Semple, C., Ma, Y.P., Barclay, E., Prendergast, J., Cazier, J.-B., Olver, B., Penegar, S., Lubbe, S., Chander, I., Carvajal-Carmona, L.G., Ballereau, S., Lloyd, A., Vijayakrishnan, J., Zgaga, L., Rudan, I., Theodoratou, E., Colorectal Tumour Gene Identification (CORGI) Consortium, Starr, J.M., Deary, I., Kirac, I., Kovacević, D., Aaltonen, L.A., Renkonen-Sinisalo, L., Mecklin, J.-P., Matsuda, K., Nakamura, Y., Okada, Y., Gallinger, S., Duggan, D.J., Conti, D., Newcomb, P., Hopper, J., Jenkins, M.A., Schumacher, F., Casey, G., Easton, D., Shah, M., Pharoah, P., Lindblom, A., Liu, T., Swedish Low-Risk Colorectal Cancer Study Group, Smith, C.G., West, H., Cheadle, J.P., COIN Collaborative Group, Midgley, R., Kerr, D.J., Campbell, H., Tomlinson, I.P., Houlston, R.S.
Journal: Nat Genet
Publication Date: 27/05/2012
Volume: 44
Issue: 7
Pages: 770-776
eISSN: 1546-1718
DOI: 10.1038/ng.2293
Abstract:We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10(-10)) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10(-10)) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.
Source: PubMed
Preferred by: Tamas Hickish
Common variation near <i>CDKN1A</i>, <i>POLD3</i> and <i>SHROOM2</i> influences colorectal cancer risk
Authors: Dunlop, M.G., Dobbins, S.E., Farrington, S.M., Jones, A.M., Palles, C., Whiffin, N., Tenesa, A., Spain, S., Broderick, P., Ooi, L.-Y., Domingo, E., Smillie, C., Henrion, M., Frampton, M., Martin, L., Grimes, G., Gorman, M., Semple, C., Ma, Y.P., Barclay, E., Prendergast, J., Cazier, J.-B., Olver, B., Penegar, S., Lubbe, S., Chander, I., Carvajal-Carmona, L.G., Ballereau, S., Lloyd, A., Vijayakrishnan, J., Zgaga, L., Rudan, I., Theodoratou, E., Starr, J.M., Deary, I., Kirac, I., Kovacevic, D., Aaltonen, L.A., Renkonen-Sinisalo, L., Mecklin, J.-P., Matsuda, K., Nakamura, Y., Okada, Y., Gallinger, S., Duggan, D.J., Conti, D., Newcomb, P., Hopper, J., Jenkins, M.A., Schumacher, F., Casey, G., Easton, D., Shah, M., Pharoah, P., Lindblom, A., Liu, T., Smith, C.G., West, H., Cheadle, J.P., Midgley, R., Kerr, D.J., Campbell, H., Tomlinson, I.P., Houlston, R.S.
Journal: NATURE GENETICS
Publication Date: 07/2012
Volume: 44
Issue: 7
Pages: 770-U197
eISSN: 1546-1718
ISSN: 1061-4036
DOI: 10.1038/ng.2293
Source: Web of Science
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.
Authors: Dunlop, M.G., Dobbins, S.E., Farrington, S.M., Jones, A.M., Palles, C., Whiffin, N., Tenesa, A., Spain, S., Broderick, P., Ooi, L.-Y., Domingo, E., Smillie, C., Henrion, M., Frampton, M., Martin, L., Grimes, G., Gorman, M., Semple, C., Ma, Y.P., Barclay, E., Prendergast, J., Cazier, J.-B., Olver, B., Penegar, S., Lubbe, S., Chander, I., Carvajal-Carmona, L.G., Ballereau, S., Lloyd, A., Vijayakrishnan, J., Zgaga, L., Rudan, I., Theodoratou, E., Colorectal Tumour Gene Identification (CORGI) Consortium, Starr, J.M., Deary, I., Kirac, I., Kovacević, D., Aaltonen, L.A., Renkonen-Sinisalo, L., Mecklin, J.-P., Matsuda, K., Nakamura, Y., Okada, Y., Gallinger, S., Duggan, D.J., Conti, D., Newcomb, P., Hopper, J., Jenkins, M.A., Schumacher, F., Casey, G., Easton, D., Shah, M., Pharoah, P., Lindblom, A., Liu, T., Swedish Low-Risk Colorectal Cancer Study Group, Smith, C.G., West, H., Cheadle, J.P., COIN Collaborative Group, Midgley, R., Kerr, D.J., Kerr, D.J., Campbell, H., Tomlinson, I.P., Houlston, R.S.
Journal: Nature genetics
Publication Date: 05/2012
Volume: 44
Issue: 7
Pages: 770-776
eISSN: 1546-1718
ISSN: 1061-4036
DOI: 10.1038/ng.2293
Abstract:We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10(-10)) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10(-10)) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.
Source: Europe PubMed Central