Application of scanning force microscopy to chromosome analysis.

Application of scanning force microscopy to chromosome analysis

Authors: McMaster, T.J., Hickish, T., Min, T., Cunningham, D., Miles, M.J.

Journal: Cancer Genetics and Cytogenetics

Publication Date: 01/01/1994

Volume: 76

Issue: 2

Pages: 93-95

ISSN: 0165-4608

DOI: 10.1016/0165-4608(94)90455-3

Abstract:

The application of scanning force microscopy (SFM) to the imaging and analysis of chromosomes is described. This relatively new microscopical technique has been used to provide high-resolution, three-dimensional images of uncoated and unstained human chromosomes in which surface features less than 50 nm have been resolved. Comparison of SFM images with light microscopy data has permitted identification of specific chromosomes, and images of a chromosome showing a cytogenetic abnormality are presented. These preliminary results demonstrate that this technique has potential applications in the imaging and analysis of chromosome structure. © 1994.

Source: Scopus

Authors: McMaster, T.J., Hickish, T., Min, T., Cunningham, D., Miles, M.J.

Journal: Cancer Genet Cytogenet

Publication Date: 09/1994

Volume: 76

Issue: 2

Pages: 93-95

ISSN: 0165-4608

DOI: 10.1016/0165-4608(94)90455-3

Abstract:

The application of scanning force microscopy (SFM) to the imaging and analysis of chromosomes is described. This relatively new microscopical technique has been used to provide high-resolution, three-dimensional images of uncoated and unstained human chromosomes in which surface features less than 50 nm have been resolved. Comparison of SFM images with light microscopy data has permitted identification of specific chromosomes, and images of a chromosome showing a cytogenetic abnormality are presented. These preliminary results demonstrate that this technique has potential applications in the imaging and analysis of chromosome structure.

Source: PubMed

Preferred by: Tamas Hickish