As time flies by: Investigating cardiac aging in the short-lived Drosophila model
Authors: Blice-Baum, A.C., Guida, M.C., Hartley, P.S., Adams, P.D., Bodmer, R., Cammarato, A.
Journal: Biochimica Et Biophysica Acta Molecular Basis of Disease
Publication Date: 01/07/2019
Volume: 1865
Issue: 7
Pages: 1831-1844
eISSN: 1879-260X
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2018.11.010
Abstract:Aging is associated with a decline in heart function across the tissue, cellular, and molecular levels. The risk of cardiovascular disease grows significantly over time, and as developed countries continue to see an increase in lifespan, the cost of cardiovascular healthcare for the elderly will undoubtedly rise. The molecular basis for cardiac function deterioration with age is multifaceted and not entirely clear, and there is a limit to what investigations can be performed on human subjects or mammalian models. Drosophila melanogaster has emerged as a useful model organism for studying aging in a short timeframe, benefitting from a suite of molecular and genetic tools and displaying highly conserved traits of cardiac senescence. Here, we discuss recent advances in our understanding of cardiac aging and how the fruit fly has aided in these developments.
https://eprints.bournemouth.ac.uk/31626/
Source: Scopus
As time flies by: Investigating cardiac aging in the short-lived Drosophila model.
Authors: Blice-Baum, A.C., Guida, M.C., Hartley, P.S., Adams, P.D., Bodmer, R., Cammarato, A.
Journal: Biochim Biophys Acta Mol Basis Dis
Publication Date: 01/07/2019
Volume: 1865
Issue: 7
Pages: 1831-1844
eISSN: 1879-260X
DOI: 10.1016/j.bbadis.2018.11.010
Abstract:Aging is associated with a decline in heart function across the tissue, cellular, and molecular levels. The risk of cardiovascular disease grows significantly over time, and as developed countries continue to see an increase in lifespan, the cost of cardiovascular healthcare for the elderly will undoubtedly rise. The molecular basis for cardiac function deterioration with age is multifaceted and not entirely clear, and there is a limit to what investigations can be performed on human subjects or mammalian models. Drosophila melanogaster has emerged as a useful model organism for studying aging in a short timeframe, benefitting from a suite of molecular and genetic tools and displaying highly conserved traits of cardiac senescence. Here, we discuss recent advances in our understanding of cardiac aging and how the fruit fly has aided in these developments.
https://eprints.bournemouth.ac.uk/31626/
Source: PubMed
As time flies by: Investigating cardiac aging in the short-lived <i>Drosophila</i> model
Authors: Blice-Baum, A.C., Guida, M.C., Hartley, P.S., Adams, P.D., Bodmer, R., Cammarato, A.
Journal: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Publication Date: 01/07/2019
Volume: 1865
Issue: 7
Pages: 1831-1844
eISSN: 1879-260X
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2018.11.010
https://eprints.bournemouth.ac.uk/31626/
Source: Web of Science
As time flies by: Investigating cardiac aging in the short-lived Drosophila model
Authors: Blice-Baum, A.C., Guida, M.C., Hartley, P., Adams, P., Bodmer, R., Cammarato, A.
Journal: BBA - Molecular Basis of Disease
Publication Date: 20/12/2018
ISSN: 0925-4439
Abstract:Aging is associated with a decline in heart function across the tissue, cellular, and molecular levels. The risk of cardiovascular disease grows significantly over time, and as developed countries continue to see an increase in lifespan, the cost of cardiovascular healthcare for the elderly will undoubtedly rise. The molecular basis for cardiac function deterioration with age is multifaceted and not entirely clear, and there is a limit to what investigations can be performed on human subjects or mammalian models. Drosophila melanogaster has emerged as a useful model organism for studying aging in a short timeframe, benefitting from a suite of molecular and genetic tools and displaying highly conserved traits of cardiac senescence. Here, we discuss recent advances in our understanding of cardiac aging and how the fruit fly has aided in these developments.
https://eprints.bournemouth.ac.uk/31626/
Source: Manual
Preferred by: Paul Hartley
As time flies by: Investigating cardiac aging in the short-lived Drosophila model.
Authors: Blice-Baum, A.C., Guida, M.C., Hartley, P.S., Adams, P.D., Bodmer, R., Cammarato, A.
Journal: Biochimica et biophysica acta. Molecular basis of disease
Publication Date: 07/2019
Volume: 1865
Issue: 7
Pages: 1831-1844
eISSN: 1879-260X
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2018.11.010
Abstract:Aging is associated with a decline in heart function across the tissue, cellular, and molecular levels. The risk of cardiovascular disease grows significantly over time, and as developed countries continue to see an increase in lifespan, the cost of cardiovascular healthcare for the elderly will undoubtedly rise. The molecular basis for cardiac function deterioration with age is multifaceted and not entirely clear, and there is a limit to what investigations can be performed on human subjects or mammalian models. Drosophila melanogaster has emerged as a useful model organism for studying aging in a short timeframe, benefitting from a suite of molecular and genetic tools and displaying highly conserved traits of cardiac senescence. Here, we discuss recent advances in our understanding of cardiac aging and how the fruit fly has aided in these developments.
https://eprints.bournemouth.ac.uk/31626/
Source: Europe PubMed Central