Long-Chain Polyunsaturated Fatty Acids and Lipid Peroxidation Products in Donor Human Milk in the United Kingdom: Results From the LIMIT 2-Centre Cross-Sectional Study
Authors: Nessel, I., De Rooy, L., Khashu, M., Murphy, J.L., Dyall, S.C.
Journal: Journal of Parenteral and Enteral Nutrition
Publication Date: 01/11/2020
Volume: 44
Issue: 8
Pages: 1501-1509
eISSN: 1941-2444
ISSN: 0148-6071
DOI: 10.1002/jpen.1773
Abstract:Background: Donor human milk (DHM) is used as alternative to maternal milk to feed preterm infants; however, it may provide less long-chain (LC) polyunsaturated fatty acids (PUFAs) and more oxidized lipids, which may be detrimental to preterm infant health and development. Levels have not been reported for DHM in the United Kingdom. Methods: DHM (n = 19) from 2 neonatal units, preterm milk from a neonatal unit (n = 10), and term milk from the community (n = 11) were analyzed for fatty acids, malondialdehyde, 4-hydroxy-2-nonenal, and hexanal. Study registration: NCT03573531. Results: DHM had significantly lower absolute LCPUFA content than term (P <.001) and significantly lower ω-3 PUFAs than preterm milk (P <.05), although relative LCPUFA composition did not differ. Exclusive DHM feeding leads to significantly lower fat (3.7 vs 6.7 g/d) and LCPUFA (docosahexaenoic acid [DHA]: 10.6 vs 16.8 mg/d; arachidonic acid [ARA]: 17.4 vs 25.2 mg/d) intake than recommended by the European Society for Pediatric Gastroenterology, Hepatology and Nutrition, and provides 17.3% and 43.1% of the in utero accreted ARA and DHA. DHM had the highest proportion of lipid peroxidation. Conclusions: This study confirms that DHM in the United Kingdom has insufficient LCPUFAs for preterm infants. It demonstrates for the first time that DHM has the highest level of lipid peroxidation, compared with preterm or term milk. This has important implications for preterm infant nutrition, as exclusive DHM feeding might not be suitable long term and may contribute to the development of major preterm neonatal morbidities.
https://eprints.bournemouth.ac.uk/33265/
Source: Scopus
Long-Chain Polyunsaturated Fatty Acids and Lipid Peroxidation Products in Donor Human Milk in the United Kingdom: Results From the LIMIT 2-Centre Cross-Sectional Study.
Authors: Nessel, I., De Rooy, L., Khashu, M., Murphy, J.L., Dyall, S.C.
Journal: JPEN J Parenter Enteral Nutr
Publication Date: 11/2020
Volume: 44
Issue: 8
Pages: 1501-1509
eISSN: 1941-2444
DOI: 10.1002/jpen.1773
Abstract:BACKGROUND: Donor human milk (DHM) is used as alternative to maternal milk to feed preterm infants; however, it may provide less long-chain (LC) polyunsaturated fatty acids (PUFAs) and more oxidized lipids, which may be detrimental to preterm infant health and development. Levels have not been reported for DHM in the United Kingdom. METHODS: DHM (n = 19) from 2 neonatal units, preterm milk from a neonatal unit (n = 10), and term milk from the community (n = 11) were analyzed for fatty acids, malondialdehyde, 4-hydroxy-2-nonenal, and hexanal. STUDY REGISTRATION: NCT03573531. RESULTS: DHM had significantly lower absolute LCPUFA content than term (P < .001) and significantly lower ω-3 PUFAs than preterm milk (P < .05), although relative LCPUFA composition did not differ. Exclusive DHM feeding leads to significantly lower fat (3.7 vs 6.7 g/d) and LCPUFA (docosahexaenoic acid [DHA]: 10.6 vs 16.8 mg/d; arachidonic acid [ARA]: 17.4 vs 25.2 mg/d) intake than recommended by the European Society for Pediatric Gastroenterology, Hepatology and Nutrition, and provides 17.3% and 43.1% of the in utero accreted ARA and DHA. DHM had the highest proportion of lipid peroxidation. CONCLUSIONS: This study confirms that DHM in the United Kingdom has insufficient LCPUFAs for preterm infants. It demonstrates for the first time that DHM has the highest level of lipid peroxidation, compared with preterm or term milk. This has important implications for preterm infant nutrition, as exclusive DHM feeding might not be suitable long term and may contribute to the development of major preterm neonatal morbidities.
https://eprints.bournemouth.ac.uk/33265/
Source: PubMed
Long-Chain Polyunsaturated Fatty Acids and Lipid Peroxidation Products in Donor Human Milk in the United Kingdom: Results From the LIMIT 2-Centre Cross-Sectional Study
Authors: Nessel, I., De Rooy, L., Khashu, M., Murphy, J.L., Dyall, S.C.
Journal: JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
Publication Date: 11/2020
Volume: 44
Issue: 8
Pages: 1501-1509
eISSN: 1941-2444
ISSN: 0148-6071
DOI: 10.1002/jpen.1773
https://eprints.bournemouth.ac.uk/33265/
Source: Web of Science
Long-chain polyunsaturated fatty acids and lipid peroxidation products in donor human milk in the U.K.: Results from the LIMIT two-centre cross sectional study. Journal of Parenteral and Enteral Nutrition
Authors: Nessell, I., Rooy, L., Khashu, M., Murphy, J., Dyall, S.C.
Journal: Journal of Parenteral and Enteral Nutrition
Publication Date: 01/03/2020
https://eprints.bournemouth.ac.uk/33265/
Source: Manual
Long-Chain Polyunsaturated Fatty Acids and Lipid Peroxidation Products in Donor Human Milk in the United Kingdom: Results From the LIMIT 2-Centre Cross-Sectional Study.
Authors: Nessel, I., De Rooy, L., Khashu, M., Murphy, J.L., Dyall, S.C.
Journal: JPEN. Journal of parenteral and enteral nutrition
Publication Date: 11/2020
Volume: 44
Issue: 8
Pages: 1501-1509
eISSN: 1941-2444
ISSN: 0148-6071
DOI: 10.1002/jpen.1773
Abstract:Background
Donor human milk (DHM) is used as alternative to maternal milk to feed preterm infants; however, it may provide less long-chain (LC) polyunsaturated fatty acids (PUFAs) and more oxidized lipids, which may be detrimental to preterm infant health and development. Levels have not been reported for DHM in the United Kingdom.Methods
DHM (n = 19) from 2 neonatal units, preterm milk from a neonatal unit (n = 10), and term milk from the community (n = 11) were analyzed for fatty acids, malondialdehyde, 4-hydroxy-2-nonenal, and hexanal.Study registration
NCT03573531.Results
DHM had significantly lower absolute LCPUFA content than term (P < .001) and significantly lower ω-3 PUFAs than preterm milk (P < .05), although relative LCPUFA composition did not differ. Exclusive DHM feeding leads to significantly lower fat (3.7 vs 6.7 g/d) and LCPUFA (docosahexaenoic acid [DHA]: 10.6 vs 16.8 mg/d; arachidonic acid [ARA]: 17.4 vs 25.2 mg/d) intake than recommended by the European Society for Pediatric Gastroenterology, Hepatology and Nutrition, and provides 17.3% and 43.1% of the in utero accreted ARA and DHA. DHM had the highest proportion of lipid peroxidation.Conclusions
This study confirms that DHM in the United Kingdom has insufficient LCPUFAs for preterm infants. It demonstrates for the first time that DHM has the highest level of lipid peroxidation, compared with preterm or term milk. This has important implications for preterm infant nutrition, as exclusive DHM feeding might not be suitable long term and may contribute to the development of major preterm neonatal morbidities.https://eprints.bournemouth.ac.uk/33265/
Source: Europe PubMed Central