Multiple loci on 8q24 associated with prostate cancer susceptibility.
Authors: Al Olama, A.A., Kote-Jarai, Z., Giles, G.G., Guy, M., Morrison, J., Severi, G., Leongamornlert, D.A., Tymrakiewicz, M., Jhavar, S., Saunders, E., Hopper, J.L., Southey, M.C., Muir, K.R., English, D.R., Dearnaley, D.P., Ardern-Jones, A.T., Hall, A.L., O'Brien, L.T., Wilkinson, R.A., Sawyer, E., Lophatananon, A., UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology, UK Prostate testing for cancer and Treatment study (ProtecT Study) Collaborators, Horwich, A., Huddart, R.A., Khoo, V.S., Parker, C.C., Woodhouse, C.J., Thompson, A., Christmas, T., Ogden, C., Cooper, C., Donovan, J.L., Hamdy, F.C., Neal, D.E., Eeles, R.A., Easton, D.F.
Journal: Nat Genet
Publication Date: 10/2009
Volume: 41
Issue: 10
Pages: 1058-1060
eISSN: 1546-1718
DOI: 10.1038/ng.452
Abstract:Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 x 10(-8); rs620861: OR = 0.90, P = 4.8 x 10(-8)). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.
Source: PubMed
Multiple loci on 8q24 associated with prostate cancer susceptibility
Authors: Al Olama, A.A., Kote-Jarai, Z., Giles, G.G., Guy, M., Morrison, J., Severi, G., Leongamornlert, D.A., Tymrakiewicz, M., Jhavar, S., Saunders, E., Hopper, J.L., Southey, M.C., Muir, K.R., English, D.R., Dearnaley, D.P., Ardern-Jones, A.T., Hall, A.L., O'Brien, L.T., Wilkinson, R.A., Sawyer, E., Lophatananon, A., Horwich, A., Huddart, R.A., Khoo, V.S., Parker, C.C., Woodhouse, C.J., Thompson, A., Christmas, T., Ogden, C., Cooper, C., Donovan, J.L., Hamdy, F.C., Neal, D.E., Eeles, R.A., Easton, D.F.
Journal: NATURE GENETICS
Publication Date: 10/2009
Volume: 41
Issue: 10
Pages: 1058-1060
eISSN: 1546-1718
ISSN: 1061-4036
DOI: 10.1038/ng.452
Source: Web of Science
Multiple loci on 8q24 associated with prostate cancer susceptibility.
Authors: Al Olama, A.A., Kote-Jarai, Z., Giles, G.G., Guy, M., Morrison, J., Severi, G., Leongamornlert, D.A., Tymrakiewicz, M., Jhavar, S., Saunders, E., Hopper, J.L., Southey, M.C., Muir, K.R., English, D.R., Dearnaley, D.P., Ardern-Jones, A.T., Hall, A.L., O'Brien, L.T., Wilkinson, R.A., Sawyer, E., Lophatananon, A., UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology, UK Prostate testing for cancer and Treatment study (ProtecT Study) Collaborators, Horwich, A., Huddart, R.A., Khoo, V.S., Parker, C.C., Woodhouse, C.J., Thompson, A., Christmas, T., Ogden, C., Cooper, C., Donovan, J.L., Hamdy, F.C., Neal, D.E., Eeles, R.A., Easton, D.F.
Journal: Nature genetics
Publication Date: 10/2009
Volume: 41
Issue: 10
Pages: 1058-1060
eISSN: 1546-1718
ISSN: 1061-4036
DOI: 10.1038/ng.452
Abstract:Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 x 10(-8); rs620861: OR = 0.90, P = 4.8 x 10(-8)). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.
Source: Europe PubMed Central