The effects of multi-nutrient formulas containing a combination of n-3 PUFA and B vitamins on cognition in the older adult: A systematic review and meta-analysis
Authors: Fairbairn, P.
Journal: British Journal of Nutrition
Publication Date: 14/02/2023
Volume: 129
Issue: 3
Pages: 428-441
eISSN: 1475-2662
ISSN: 0007-1145
DOI: 10.1017/S0007114522001283
Abstract:There is now evidence to suggest that there may be an interaction between B vitamins and n-3 PUFA, with suggestions that increasing intake of both nutrients simultaneously may benefit cognition in older adults. The aim of this systematic review was to investigate whether supplementation with a combination of n-3 PUFA and B vitamins can prevent cognitive decline in older adults. Randomised controlled trials conducted in older adults that measured cognitive function were retrieved. The included trials provided a combination of n-3 PUFA and B vitamins alone, or in combination with other nutrients. Trials that provided n-3 PUFA alone and also measured B vitamin status or provided B vitamin supplementation alone and measured n-3 PUFA status were also included. The databases searched were The Cochrane Library, EMBASE, CINAHL, Scopus and MEDLINE. A total of 14 papers were included in the analysis (n 4913; age: 60-70 years; follow-up 24 weeks to 4 years). The meta-analysis results found a significant benefit of nutrient formulas, which included both n-3 PUFA and B vitamins alongside other nutrients, v. placebo on global cognition assessed using composite scores from a neuropsychological test battery (G = 0·23, P = 0·002), global cognition using single measures of cognition (G = 0·28, P = 0·004) and episodic memory (G = 0·32, P = 0·001). The results indicate that providing a combination of n-3 PUFA and B vitamins as part of a multi-nutrient formula benefits cognition in older adults v. a placebo, and the potential for an interaction between these key nutrients should be considered in future experimental work.
https://eprints.bournemouth.ac.uk/36903/
Source: Scopus
The effects of multi-nutrient formulas containing a combination of n-3 PUFA and B vitamins on cognition in the older adult: a systematic review and meta-analysis.
Authors: Fairbairn, P., Dyall, S.C., Tsofliou, F.
Journal: Br J Nutr
Publication Date: 14/02/2023
Volume: 129
Issue: 3
Pages: 428-441
eISSN: 1475-2662
DOI: 10.1017/S0007114522001283
Abstract:There is now evidence to suggest that there may be an interaction between B vitamins and n-3 PUFA, with suggestions that increasing intake of both nutrients simultaneously may benefit cognition in older adults. The aim of this systematic review was to investigate whether supplementation with a combination of n-3 PUFA and B vitamins can prevent cognitive decline in older adults. Randomised controlled trials conducted in older adults that measured cognitive function were retrieved. The included trials provided a combination of n-3 PUFA and B vitamins alone, or in combination with other nutrients. Trials that provided n-3 PUFA alone and also measured B vitamin status or provided B vitamin supplementation alone and measured n-3 PUFA status were also included. The databases searched were The Cochrane Library, EMBASE, CINAHL, Scopus and MEDLINE. A total of 14 papers were included in the analysis (n 4913; age: 60-70 years; follow-up 24 weeks to 4 years). The meta-analysis results found a significant benefit of nutrient formulas, which included both n-3 PUFA and B vitamins alongside other nutrients, v. placebo on global cognition assessed using composite scores from a neuropsychological test battery (G = 0·23, P = 0·002), global cognition using single measures of cognition (G = 0·28, P = 0·004) and episodic memory (G = 0·32, P = 0·001). The results indicate that providing a combination of n-3 PUFA and B vitamins as part of a multi-nutrient formula benefits cognition in older adults v. a placebo, and the potential for an interaction between these key nutrients should be considered in future experimental work.
https://eprints.bournemouth.ac.uk/36903/
Source: PubMed
The effects of multi-nutrient formulas containing a combination of <i>n</i>-3 PUFA and B vitamins on cognition in the older adult: a systematic review and meta-analysis
Authors: Fairbairn, P., Dyall, S.C., Tsofliou, F.
Journal: BRITISH JOURNAL OF NUTRITION
Publication Date: 14/02/2023
Volume: 129
Issue: 3
Pages: 428-441
eISSN: 1475-2662
ISSN: 0007-1145
DOI: 10.1017/S0007114522001283
https://eprints.bournemouth.ac.uk/36903/
Source: Web of Science
The Effects of Multi-Nutrient Formulas containing a Combination of Omega-3 Polyunsaturated Fatty Acids and B vitamins on Cognition in the older adult: A Systematic Review and Meta-analysis
Authors: Fairbairn, P., Dyall, S., Tsofliou, F.
Journal: The British Journal of Nutrition: an international journal of nutritional science
Publication Date: 08/05/2022
Publisher: Cambridge University Press
ISSN: 0007-1145
https://eprints.bournemouth.ac.uk/36903/
Source: Manual
The effects of multi-nutrient formulas containing a combination of <i>n</i>-3 PUFA and B vitamins on cognition in the older adult: a systematic review and meta-analysis.
Authors: Fairbairn, P., Dyall, S.C., Tsofliou, F.
Journal: The British journal of nutrition
Publication Date: 02/2023
Volume: 129
Issue: 3
Pages: 428-441
eISSN: 1475-2662
ISSN: 0007-1145
DOI: 10.1017/s0007114522001283
Abstract:There is now evidence to suggest that there may be an interaction between B vitamins and n-3 PUFA, with suggestions that increasing intake of both nutrients simultaneously may benefit cognition in older adults. The aim of this systematic review was to investigate whether supplementation with a combination of n-3 PUFA and B vitamins can prevent cognitive decline in older adults. Randomised controlled trials conducted in older adults that measured cognitive function were retrieved. The included trials provided a combination of n-3 PUFA and B vitamins alone, or in combination with other nutrients. Trials that provided n-3 PUFA alone and also measured B vitamin status or provided B vitamin supplementation alone and measured n-3 PUFA status were also included. The databases searched were The Cochrane Library, EMBASE, CINAHL, Scopus and MEDLINE. A total of 14 papers were included in the analysis (n 4913; age: 60-70 years; follow-up 24 weeks to 4 years). The meta-analysis results found a significant benefit of nutrient formulas, which included both n-3 PUFA and B vitamins alongside other nutrients, v. placebo on global cognition assessed using composite scores from a neuropsychological test battery (G = 0·23, P = 0·002), global cognition using single measures of cognition (G = 0·28, P = 0·004) and episodic memory (G = 0·32, P = 0·001). The results indicate that providing a combination of n-3 PUFA and B vitamins as part of a multi-nutrient formula benefits cognition in older adults v. a placebo, and the potential for an interaction between these key nutrients should be considered in future experimental work.
https://eprints.bournemouth.ac.uk/36903/
Source: Europe PubMed Central