Deficits in Spontaneous Cognition as an Early Marker of Alzheimer's Disease
Authors: Kvavilashvili, L., Niedźwieńska, A., Gilbert, S.J., Markostamou, I.
Journal: Trends in Cognitive Sciences
Publication Date: 01/04/2020
Volume: 24
Issue: 4
Pages: 285-301
eISSN: 1879-307X
ISSN: 1364-6613
DOI: 10.1016/j.tics.2020.01.005
Abstract:In the absence of a pharmacological cure, finding the most sensitive early cognitive markers of Alzheimer's disease (AD) is becoming increasingly important. In this article we review evidence showing that brain mechanisms of spontaneous, but stimulus-dependent, cognition overlap with key hubs of the default mode network (DMN) that become compromised by amyloid pathology years before the clinical symptoms of AD. This leads to the formulation of a novel hypothesis which predicts that spontaneous, but stimulus-dependent, conscious retrieval processes, that are generally intact in healthy aging, will be particularly compromised in people at the earliest stages of AD. Initial evidence for this hypothesis is presented across diverse experimental paradigms (e.g., prospective memory, mind-wandering), and new avenues for research in this area are outlined.
https://eprints.bournemouth.ac.uk/39406/
Source: Scopus
Deficits in Spontaneous Cognition as an Early Marker of Alzheimer's Disease.
Authors: Kvavilashvili, L., Niedźwieńska, A., Gilbert, S.J., Markostamou, I.
Journal: Trends Cogn Sci
Publication Date: 04/2020
Volume: 24
Issue: 4
Pages: 285-301
eISSN: 1879-307X
DOI: 10.1016/j.tics.2020.01.005
Abstract:In the absence of a pharmacological cure, finding the most sensitive early cognitive markers of Alzheimer's disease (AD) is becoming increasingly important. In this article we review evidence showing that brain mechanisms of spontaneous, but stimulus-dependent, cognition overlap with key hubs of the default mode network (DMN) that become compromised by amyloid pathology years before the clinical symptoms of AD. This leads to the formulation of a novel hypothesis which predicts that spontaneous, but stimulus-dependent, conscious retrieval processes, that are generally intact in healthy aging, will be particularly compromised in people at the earliest stages of AD. Initial evidence for this hypothesis is presented across diverse experimental paradigms (e.g., prospective memory, mind-wandering), and new avenues for research in this area are outlined.
https://eprints.bournemouth.ac.uk/39406/
Source: PubMed
Deficits in Spontaneous Cognition as an Early Marker of Alzheimer's Disease
Authors: Kvavilashvili, L., Niedzwienska, A., Gilbert, S.J., Markostamou, I.
Journal: TRENDS IN COGNITIVE SCIENCES
Publication Date: 2020
Volume: 24
Issue: 4
Pages: 285-301
eISSN: 1879-307X
ISSN: 1364-6613
DOI: 10.1016/j.tics.2020.01.005
https://eprints.bournemouth.ac.uk/39406/
Source: Web of Science
Deficits in Spontaneous Cognition as an Early Marker of Alzheimer's Disease.
Authors: Kvavilashvili, L., Niedźwieńska, A., Gilbert, S.J., Markostamou, I.
Journal: Trends in cognitive sciences
Publication Date: 04/2020
Volume: 24
Issue: 4
Pages: 285-301
eISSN: 1879-307X
ISSN: 1364-6613
DOI: 10.1016/j.tics.2020.01.005
Abstract:In the absence of a pharmacological cure, finding the most sensitive early cognitive markers of Alzheimer's disease (AD) is becoming increasingly important. In this article we review evidence showing that brain mechanisms of spontaneous, but stimulus-dependent, cognition overlap with key hubs of the default mode network (DMN) that become compromised by amyloid pathology years before the clinical symptoms of AD. This leads to the formulation of a novel hypothesis which predicts that spontaneous, but stimulus-dependent, conscious retrieval processes, that are generally intact in healthy aging, will be particularly compromised in people at the earliest stages of AD. Initial evidence for this hypothesis is presented across diverse experimental paradigms (e.g., prospective memory, mind-wandering), and new avenues for research in this area are outlined.
https://eprints.bournemouth.ac.uk/39406/
Source: Europe PubMed Central