Brown fat activity determined by infrared thermography and thermogenesis measurement using whole body calorimetry (bright study)
Authors: Tay, S.H., Goh, H.J., Govindharajulu, P., Cheng, J., Camps, S.G.J.A., Haldar, S., Velan, S.S., Sun, L., Li, Y., Henry, C.J., Leow, M.K.S.
Journal: Physiological Research
Publication Date: 01/02/2020
Volume: 69
Issue: 1
Pages: 85-97
eISSN: 1802-9973
ISSN: 0862-8408
DOI: 10.33549/physiolres.934190
Abstract:To assess BAT activity in humans at a population level, infrared thermography (IRT) represents a safe, readily repeatable and affordable alternative to 18F-FDG-PET. Building upon a previously proposed method by our laboratory, we further refined the image computational algorithm to quantify BAT activation in the cervical-supraclavicular (C-SCV) region of healthy young men under thermo-neutral and cold exposure conditions. Additionally, we validated the whole-body calorimeter (WBC) in reliably measuring cold-induced thermogenesis. The temperature gradient between C-SCV-deltoid regions, and the corresponding difference in heat power output, increased upon cold air exposure relative to thermo-neutral conditions (by 74.88 %, p<0.0001; and by 71.34 %, p<0.0001 respectively). Resting and cumulative energy expenditure (EE) rose significantly (by 13.14 % and 9.12 % respectively, p=0.0001) while positive correlations between IRT measures and EE were found with cold air exposure (percentage change in heat power gradient between ROI and deltoid, cold air: r2=0.29, p=0.026, Pearson's correlation). IRT and WBC can be used to study BAT activation. The refined algorithm allows for more automation and objectivity in IRT data analysis, especially under cold air exposures.
Source: Scopus
Brown fat activity determined by infrared thermography and thermogenesis measurement using whole body calorimetry (BRIGHT Study).
Authors: Tay, S.H., Goh, H.J., Govindharajulu, P., Cheng, J., Camps, S.G., Haldar, S., Velan, S.S., Sun, L., Li, Y., Henry, C.J., Leow, M.K.-S.
Journal: Physiol Res
Publication Date: 19/02/2020
Volume: 69
Issue: 1
Pages: 85-97
eISSN: 1802-9973
DOI: 10.33549/physiolres.934190
Abstract:To assess BAT activity in humans at a population level, infrared thermography (IRT) represents a safe, readily repeatable and affordable alternative to 18F-FDG-PET. Building upon a previously proposed method by our laboratory, we further refined the image computational algorithm to quantify BAT activation in the cervical-supraclavicular (C-SCV) region of healthy young men under thermo-neutral and cold exposure conditions. Additionally, we validated the whole-body calorimeter (WBC) in reliably measuring cold-induced thermogenesis. The temperature gradient between C-SCV-deltoid regions, and the corresponding difference in heat power output, increased upon cold air exposure relative to thermo-neutral conditions (by 74.88 %, p<0.0001; and by 71.34 %, p<0.0001 respectively). Resting and cumulative energy expenditure (EE) rose significantly (by 13.14 % and 9.12 % respectively, p=0.0001) while positive correlations between IRT measures and EE were found with cold air exposure (percentage change in heat power gradient between ROI and deltoid, cold air: r(2)=0.29, p=0.026, Pearson's correlation). IRT and WBC can be used to study BAT activation. The refined algorithm allows for more automation and objectivity in IRT data analysis, especially under cold air exposures.
Source: PubMed
Brown fat activity determined by infrared thermography and thermogenesis measurement using whole body calorimetry (BRIGHT Study).
Authors: Tay, S.H., Goh, H.J., Govindharajulu, P., Cheng, J., Camps, S.G., Haldar, S., Velan, S.S., Sun, L., Li, Y., Henry, C.J., Leow, M.K.-S.
Journal: Physiological research
Publication Date: 02/2020
Volume: 69
Issue: 1
Pages: 85-97
eISSN: 1802-9973
ISSN: 0862-8408
DOI: 10.33549/physiolres.934190
Abstract:To assess BAT activity in humans at a population level, infrared thermography (IRT) represents a safe, readily repeatable and affordable alternative to 18F-FDG-PET. Building upon a previously proposed method by our laboratory, we further refined the image computational algorithm to quantify BAT activation in the cervical-supraclavicular (C-SCV) region of healthy young men under thermo-neutral and cold exposure conditions. Additionally, we validated the whole-body calorimeter (WBC) in reliably measuring cold-induced thermogenesis. The temperature gradient between C-SCV-deltoid regions, and the corresponding difference in heat power output, increased upon cold air exposure relative to thermo-neutral conditions (by 74.88 %, p<0.0001; and by 71.34 %, p<0.0001 respectively). Resting and cumulative energy expenditure (EE) rose significantly (by 13.14 % and 9.12 % respectively, p=0.0001) while positive correlations between IRT measures and EE were found with cold air exposure (percentage change in heat power gradient between ROI and deltoid, cold air: r(2)=0.29, p=0.026, Pearson's correlation). IRT and WBC can be used to study BAT activation. The refined algorithm allows for more automation and objectivity in IRT data analysis, especially under cold air exposures.
Source: Europe PubMed Central