Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk
Authors: Dunlop, M.G., Dobbins, S.E., Farrington, S.M., Jones, A.M., Palles, C., Whiffin, N., Tenesa, A., Spain, S., Broderick, P., Ooi, L.Y., Domingo, E., Smillie, C., Henrion, M., Frampton, M., Martin, L., Grimes, G., Gorman, M., Semple, C., Ma, Y.P., Barclay, E., Prendergast, J., Cazier, J.B., Olver, B., Penegar, S., Lubbe, S., Chander, I., Carvajal-Carmona, L.G., Ballereau, S., Lloyd, A., Vijayakrishnan, J., Zgaga, L., Rudan, I., Theodoratou, E., Thomas, H., Maher, E., Evans, G., Walker, L., Halliday, D., Lucassen, A., Paterson, J., Hodgson, S., Homfray, T., Side, L., Izatt, L., Donaldson, A., Tomkins, S., Morrison, P., Brewer, C., Henderson, A., Davidson, R., Murday, V., Cook, J., Haites, N., Bishop, T., Sheridan, E., Green, A., Marks, C., Carpenter, S., Broughton, M., Greenhalge, L., Suri, M., Starr, J.M., Deary, I., Kirac, I., Kovacevia, D., Aaltonen, L.A., Renkonen-Sinisalo, L., Mecklin, J.P., Matsuda, K., Nakamura, Y., Okada, Y., Gallinger, S., Duggan, D.J., Conti, D., Newcomb, P., Hopper, J., Jenkins, M.A., Schumacher, F., Casey, G., Easton, D., Shah, M., Pharoah, P., Lindblom, A., Liu, T., Edler, D., Lenander, C., Dalén, J., Hjern, F., Lundqvist, N., Lindforss, U., Påhlman, L., Smedh, K., Törnqvist, A., Holm, J., Janson, M., Andersson, M., Ekelund, S., Olsson, L., Smith, C.G., West, H.
Journal: Nature Genetics
Publication Date: 01/07/2012
Volume: 44
Issue: 7
Pages: 770-776
eISSN: 1546-1718
ISSN: 1061-4036
DOI: 10.1038/ng.2293
Abstract:We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10 -10), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10 -10) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10 -10) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC. © 2012 Nature America, Inc. All rights reserved.
Source: Scopus
Preferred by: Tamas Hickish